{"id":5410,"date":"2021-03-10T12:14:28","date_gmt":"2021-03-10T04:14:28","guid":{"rendered":"https:\/\/lindin168.com\/?page_id=5410"},"modified":"2021-03-10T12:14:41","modified_gmt":"2021-03-10T04:14:41","slug":"dull-skin-zh-cn","status":"publish","type":"page","link":"https:\/\/lindin168.com\/zh\/develop-zh-cn\/dull-skin-zh-cn","title":{"rendered":"\u76ae\u80a4\u6697\u6c89"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
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\u76ae\u80a4\u6697\u6c89~ \u300e\u7cd6\u5316\u4f5c\u7528\u300f\u5b66\u8bf4<\/font><\/font><\/h2>\n

\u7cd6\u5316\u4f5c\u7528\u53c8\u79f0\u6885\u7eb3\u53cd\u5e94(Maillard reaction)<\/font><\/font><\/span><\/h2>\n

\u7cd6\u4e0e\u86cb\u767d\u8d28\u5728\u52a0\u70ed\u4e0b\u4f1a\u4ea7\u751f\u4e00\u8fde\u4e32\u805a\u5408\u4f5c\u7528\uff0c\u53d8\u6210\u68d5\u8272\u7684\u8910\u53d8\u7269\u8d28\u7c7b\u9ed1\u8272\u7d20(melanoidin)\uff0c\u79f0\u4e3a\u7cd6\u5316(\u6885\u7eb3)\u53cd\u5e94\uff0c\u5728\u98df\u54c1\u52a0\u5de5\u4e0a\u662f\u5f88\u91cd\u8981\u7684\u8457\u8272\u4e0e\u98ce\u5473\u4f5c\u7528\u3002<\/font>\u800c\u8fd9\u4e9b\u6885\u7eb3\u53cd\u5e94\u6700\u7ec8\u4ea7\u7269\u7edf\u79f0AGEs(Advanced Glycation End Products)<\/font><\/font><\/span>
\n<\/a><\/p>\n

AGEs (Advanced Glycation End Products) \u2013 \u9ad8\u5ea6\u7cd6\u5316\u7ec8\u4ea7\u7269\u7684\u5f71\u54cd-1<\/font><\/font><\/h3>\n
\n

\u80f6\u539f\u86cb\u767d\u4e0e\u5f39\u529b\u86cb\u767d\u7684\u7cd6\u5316<\/font><\/font><\/h2>\n

\u4eba\u7c7b\u76ae\u80a4\u4f1a\u968f\u7740\u5e74\u9f84\u589e\u52a0\u800c\u9020\u6210AGEs\u84c4\u79ef\uff0c\u5bfc\u81f4\u76ae\u80a4\u7ec6\u80de\u4f24\u5bb3\u4e0e\u8001\u5316\uff0c\u7834\u574f\u80f6\u539f\u86cb\u767d\u4e0e\u5f39\u529b\u86cb\u767d\u7ea4\u7ef4\uff0c\u5931\u53bb\u5e94\u6709\u7684\u5f39\u529b\u4e0e\u5f20\u529b\u4f5c\u7528\uff0c\u4ea7\u751f\u76b1\u7eb9\u4e0e\u677e\u5f1b\u3002<\/font>\u5f53\u4f53\u5185AGEs\u4e0e\u80f6\u539f\u86cb\u767d\u7ed3\u5408\u65f6\u4f1a\u88ab\u5224\u5b9a\u4e3a\u5f02\u7269\u800c\u589e\u52a0\u80f6\u539f\u86cb\u767d\u3001\u5f39\u529b\u86cb\u767d\u5206\u89e3\u9175\u7d20\u7684\u5206\u6ccc\uff0c\u4e0d\u4ec5\u6b63\u5e38\u7684\u80f6\u539f\u86cb\u767d\u53ca\u5f39\u529b\u86cb\u767d\u4f1a\u88ab\u5206\u89e3\uff0c\u751a\u81f3\u8bf1\u5bfc\u4ea7\u751f\u80f6\u539f\u86cb\u767d\u7684\u7ea4\u7ef4\u82bd\u7ec6\u80de\u51cb\u96f6\u6b7b\u4ea1\uff0c<\/font><\/font>\u9020\u6210\u808c\u80a4\u5931\u53bb\u5f39\u529b\u4e0e\u5f20\u529b\u4f5c\u7528\uff0c\u4ea7\u751f\u677e\u5f1b\u3001\u76b1\u7eb9\u3001\u6697\u6c89\u3001\u8001\u4eba\u6591\u3001\u96c0\u6591\u3002<\/font><\/font><\/span><\/span><\/p>\n

<\/a><\/p>\n

AGEs(Advanced Glycation End Products)-\u9ad8\u5ea6\u7cd6\u5316\u7ec8\u4ea7\u7269\u7684\u5f71\u54cd-2<\/font><\/font><\/h3>\n
\n

\u7cd6\u5c3f\u75c5\u53ca\u8001\u5316\u75be\u75c5<\/font><\/font><\/h2>\n

\u5bf9\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e0e\u5065\u5eb7\u4eba\u4e4b\u76ae\u80a4\u6240\u84c4\u79ef\u7684AGE\u8fdb\u884c\u8c03\u67e5\uff0c\u5176\u62a5\u544a\u7ed3\u679c\u53d9\u8ff0\uff0c<\/font><\/font>\u5e74\u9f84\u7684\u589e\u52a0\u4e0eAGE\u84c4\u79ef\u662f\u6709\u76f8\u5173\u6027\u7684<\/font><\/font><\/span>\u3002<\/font>\u9488\u5bf9\u80f6\u539f\u86cb\u767d\u4e4b\u80fa\u57fa\u9178(\u79bb\u80fa\u9178lysine)\u603b\u91cf\u4e0e\u4ee3\u8868AGEs\u7684Carboxymethyllysine(CML)\u4e0ePentsidine\u7684\u6bd4\u7387\u5206\u6790\u3002<\/font><\/font><\/span><\/p>\n

<\/a><\/p>\n

\n

\u6a31\u82b1\u8403\u53d6\u7269sakura extract<\/font><\/font><\/h2>\n

<\/a>
\n\u6a31\u82b1\uff0c\u6a31\u82b1\u5c5e\u8537\u8587\u79d1\u7684\u690d\u7269\uff0c\u662f\u8c61\u5f81\u65e5\u672c\u7684\u82b1\uff0c\u8273\u4e3d\u4e4b\u4e2d\u5e26\u6709\u6e29\u67d4\u6c14\u8d28\u3001\u4f1a\u8ba9\u4eba\u60f3\u8d77\u65e5\u672c\u4f20\u7edf\u4e4b\u7f8e\u7684\u82b1\u3002<\/font><\/font><\/span>
\nORYZA\u6cb9\u5316\u682a\u5f0f\u4f1a\u793e\u4e0e\u4eac\u90fd\u836f\u79d1\u5927\u5b66\u4e13\u7814\u751f\u836f\u5b66\uff08\u5929\u7136\u836f\u7269\u5b66\uff09\u73b0\u4efb\u65e5\u672c\u751f\u836f\u5b66\u4f1a\u4f1a\u957f\u5409\u5ddd\u96c5\u4e4b\u535a\u58eb\u5171\u540c\u7814\u7a76\uff0c\u8ba9\u6709\u751f\u547d\u671d\u6c14\u4e4b\u6a31\u82b1\u7684\u6210\u4efd\u4e0e\u673a\u80fd\u6027\u80fd\u5e7f\u6cdb\u7684\u5e94\u7528\u4e8e\u7f8e\u5bb9\u98df\u54c1\u53ca\u5316\u5986\u54c1\u3002<\/font><\/font><\/span>
\n\u4ee5\u5173\u5c71\u4e3a\u4e2d\u5fc3\u7684\u65e5\u672c\u539f\u4ea7\u7684\u516b\u91cd\u6a31\u4e3a\u4e3b\uff0c\u4e3b\u8981\u662f\u91c7\u6536\u4e03\u5206\u5f00\u7684\u82b1\uff0c\u4e3a\u98df\u54c1\u7ea7\u539f\u6599\u7d20\u6750\uff0c\u4e0e\u4e00\u822c\u5916\u7528\u54c1\u6216\u5316\u5986\u54c1\u53d6\u6750\u7684\u6a31\u82b1\u662f\u4e0d\u540c\u7684\u54c1\u79cd\u6765\u6e90\u3002<\/font><\/font><\/span><\/p>\n

\u4e3b\u8981\u529f\u6548\u6210\u4efd<\/font><\/font><\/h3>\n

<\/a><\/p>\n

\n

\u3010\u5b9e\u9a8c\u4e00\u3011\u6291\u5236AGE\u4ea7\u751f<\/font><\/font><\/h3>\n

\u3010\u5b9e\u9a8c\u65b9\u6cd5\u3011<\/font><\/font><\/strong>
\nD- Glucose\u4e0e\u542b\u6709\u725b\u8840\u6e05\u767d\u86cb\u767d\u7684\u7f13\u51b2\u6db2\u91cc\u6dfb\u52a0\u6837\u672c\u6eb6\u6db2\uff0c\u572860\u2103\u4e0b\u9759\u7f6e2\u5929\u3002<\/font>\u53cd\u5e94\u6db2\u4ee5\u7cbe\u5236\u6c34\u7a00\u91ca\u91cf\u6d4b\u5176\u8424\u5149\u5149\u91cf\u5ea6\u3002<\/font><\/font><\/p>\n

\u3010\u5b9e\u9a8c\u7ed3\u679c\u3011<\/font><\/font><\/strong><\/p>\n

(1) \u6a31\u82b1\u8403\u53d6\u7269\u4e0e\u5176\u542b\u6709\u7684\u4e3b\u8981\u6210\u5206\uff0c\u6709\u6d53\u5ea6\u6027\u6291\u5236AGE\u4ea7\u751f\u7684\u76f8\u5173\u503e\u5411\u3002<\/font><\/font><\/p>\n\n\n\n\n\n\n\n
<\/td>\nAGE\u4ea7\u751f\u6291\u5236\u7387\uff08%\uff09<\/font><\/font><\/strong><\/td>\nIC50 <\/font><\/font><\/strong><\/td>\n<\/tr>\n
10 (\u03bcg\/mL\uff09<\/font><\/font><\/td>\n30(\u03bcg\/mL\uff09<\/font><\/font><\/td>\n100(\u03bcg\/mL)<\/font><\/font><\/td>\n300(\u03bcg\/mL)<\/font><\/font><\/td>\n\uff08\u03bcg\/m\uff09<\/font><\/font><\/td>\n<\/tr>\n
\u6a31\u82b1\u8403\u53d6\u7269<\/font><\/font><\/td>\n-10.8\u00b10.4<\/font><\/font><\/td>\n-9.9\u00b10.6<\/font><\/font><\/td>\n15.1\u00b10.7**<\/font><\/font><\/td>\n42.6\u00b13.2**<\/font><\/font><\/td>\n>300<\/font><\/font><\/td>\n<\/tr>\n
1-caffeoyl-O-\u03b2-D-glucopyranoside<\/font><\/font><\/td>\n10.7\u00b10.1**<\/font><\/font><\/td>\n19.5\u00b10.3**<\/font><\/font><\/td>\n25.0\u00b10.3**<\/font><\/font><\/td>\n30.0\u00b10.4**<\/font><\/font><\/td>\n>300<\/font><\/font><\/td>\n<\/tr>\n
quercetin 3-O-\u03b2-D-glucopyranoside<\/font><\/font><\/td>\n27.6\u00b10.5**<\/font><\/font><\/td>\n49.8\u00b10.7**<\/font><\/font><\/td>\n74.2\u00b11.1**<\/font><\/font><\/td>\n100.8\u00b10.6**<\/font><\/font><\/td>\n30<\/font><\/font><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u25ce\u5404\u5024\u7684\u663e\u793a\u662f\u4ee53\u4f8b\u7684\u5e73\u5747\u5024\u4e0e\u6807\u51c6\u8bef\u5dee\u6240\u8ba1\u3002<\/font><\/font>
\n\u661f\u53f7\u662f\u4f9d\u636e\u6837\u54c1\u672a\u5904\u7406\u7fa4\u4e0eDunnett\u7684\u591a\u91cd\u6bd4\u8f83\u68c0\u5b9a\u4e4b\u663e\u8457\u5dee\u6807\u793a*: p<0.05, **: p<0.01\u3002<\/font><\/font><\/span><\/p>\n

(2)\u6a31\u82b1\u8403\u53d6\u7269100 \u03bcg\/mL\u4ee5\u4e0a\u5177\u6709\u663e\u8457\u7684AGE\u4ea7\u751f\u6291\u5236\u4f5c\u7528\uff0c\u5176\u4e3b\u6210\u5206\u4e4b1-caffeoyl-O-\u03b2-D-glucopyranoside\u4e0equercetin 3-O-\u03b2-D-glucopyranoside\u572810\u03bcg\/mL\u4ee5\u4e0a\u5177\u6709\u663e\u8457\u7684AGE\u4ea7\u751f\u6291\u5236\u4f5c\u7528\u3002<\/font><\/font>
\n<\/a><\/p>\n<\/div>\n

(3)\u4eceAGE\u4ea7\u751f\u7684\u6291\u5236\u7387\u6570\u5024\u89e3\u6790\u663e\u793a\uff0c2\u4e2a\u6307\u6807\u6210\u5206\u7684\u6291\u5236\u8d21\u732e\u7387\u4e3a93.3\uff05\uff0c\u6a31\u82b1\u8403\u53d6\u7269\u7684AGE\u4ea7\u751f\u6291\u5236\u4f5c\u7528\u51e0\u4e4e\u5360\u636e\u5927\u90e8\u5206\u3002<\/font><\/font><\/p>\n

\n\n\n\n\n\n\n\n
<\/td>\nAGE\u4ea7\u751f\u6291\u5236\u7387\uff08%\uff09<\/font><\/font><\/strong><\/td>\nIC50 <\/font><\/font><\/strong><\/td>\n\u8403\u53d6\u7269\u542b\u91cf(%)<\/font><\/font><\/td>\n\u8d21\u732e\u91cf10(%)<\/font><\/font><\/td>\n<\/tr>\n
10 (\u03bcg\/mL\uff09<\/font><\/font><\/td>\n30(\u03bcg\/mL\uff09<\/font><\/font><\/td>\n\uff08\u03bcg\/m\uff09<\/font><\/font><\/td>\n<\/tr>\n
\u6a31\u82b1\u8403\u53d6\u7269<\/font><\/font><\/td>\n-10.8\u00b10.4<\/font><\/font><\/td>\n15.1\u00b10.7**<\/font><\/font><\/td>\n>300<\/font><\/font><\/td>\n100.0<\/font><\/font><\/td>\n100<\/font><\/font><\/td>\n<\/tr>\n
1-caffeoyl-O-\u03b2-D-glucopyranoside<\/font><\/font><\/td>\n10.7\u00b10.1**<\/font><\/font><\/td>\n25.0\u00b10.3**<\/font><\/font><\/td>\n>300<\/font><\/font><\/td>\n10.2<\/font><\/font><\/td>\n72.3<\/font><\/font><\/td>\n<\/tr>\n
quercetin 3-O-\u03b2-D-glucopyranoside<\/font><\/font><\/td>\n27.6\u00b10.5**<\/font><\/font><\/td>\n74.2\u00b11.1**<\/font><\/font><\/td>\n30<\/font><\/font><\/td>\n1.15<\/font><\/font><\/td>\n21.0<\/font><\/font><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u25ce\u5404\u5024\u7684\u663e\u793a\u662f\u4ee53\u4f8b\u7684\u5e73\u5747\u5024\u4e0e\u6807\u51c6\u8bef\u5dee\u6240\u8ba1\u3002<\/font><\/font>
\n\u661f\u53f7\u662f\u4f9d\u636e\u6837\u54c1\u672a\u5904\u7406\u7fa4\u4e0eDunnett\u7684\u591a\u91cd\u6bd4\u8f83\u68c0\u5b9a\u4e4b\u663e\u8457\u5dee\u6807\u793a*: p<0.05, **: p<0.01\u3002<\/font><\/font><\/span><\/p>\n<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

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